I only checked my level after the tret fight (lv9), but I think I was was lv7ish for most of the tree, having leveled up to 8 near the end, and then again vs tret. I checked with the editor, and indeed it should be lv8 that isaac starts to outspeed the bees. I think if you dropped bee agility by 4 to let isaac outspeed them one level sooner, it would make that enemy a lot more reasonable.
This is what I'd do:
Drone Bee: 43 agility -> 39
Troll: 144 HP -> 129, 10 regen -> 15
Ghoul: 141 HP -> 111
Grizzly: 155 HP -> 135
Amaze: Ghostly Rumble (2) base damage 15 -> 13
Tret: 1012 HP -> 922 HP
This makes the Troll and Grizzly reliably one-roundable if you focus three psynergy on them, unlike at present which absolutely requires either a summon or double-hit gust. Same for the Ghoul, who is frankly well above the curve for that point of the game, and has absolutely no business being that tanky while also being able to drain tank with high damage. At 111, it should die to a double-hit gust + off-range aoe, or to three focused aoe psynergy. The slight nerf to Ghostly Rumble is simply to reduce the ambient damage from Amaze while you focus on other, bigger threats.
This is what I'd do:
Drone Bee: 43 agility -> 39
Troll: 144 HP -> 129, 10 regen -> 15
Ghoul: 141 HP -> 111
Grizzly: 155 HP -> 135
Amaze: Ghostly Rumble (2) base damage 15 -> 13
Tret: 1012 HP -> 922 HP
This makes the Troll and Grizzly reliably one-roundable if you focus three psynergy on them, unlike at present which absolutely requires either a summon or double-hit gust. Same for the Ghoul, who is frankly well above the curve for that point of the game, and has absolutely no business being that tanky while also being able to drain tank with high damage. At 111, it should die to a double-hit gust + off-range aoe, or to three focused aoe psynergy. The slight nerf to Ghostly Rumble is simply to reduce the ambient damage from Amaze while you focus on other, bigger threats.