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That little patch worked like a charm!  I was able to test it by casting Poison on the enemy party and by also having a Ghost cast Weaken on my own party, both times it would freeze previously but not with this patch applied.  I can test TLA later, but I'm a little busy at the moment to be able to sit down long enough to try some things.  Thank you so much for the rapid help, I'm so excited to keep playing now!

Thanks for the help.  I've tried an older version of VBA, it was 1.8 I believe, but the audio issues got worse and worse no matter how I played with them, but they synched correctly at least.  But now it's heavily artifacted and sounds terrible.  I've tried troubleshooting as best I can, but no avail.  When I tried the latest version of VisualBoy advance again, it just crashes when it tries to load any ROM, I don't know what's up with that.  Runs great on mGBA still, but I keep encountering the bug.

I'm encountering a problem with Golden Sun Reloaded and I'm hoping I can at least alert people to it or can help me troubleshoot.  I primarily use mGBA for emulation and I'm trying to play Reloaded on it.  It runs phenomenally until a stat debuff happens, the game freezes up and I can't continue play.  It happens 100% of the time, no matter who's side the debuff happens.  I first encountered it in the 3 Thieves fight when one of them used Smoke Bomb.  It happened again when I attempted to cast Poison on an enemy.  It also happens when Ghost uses Impair, but not when Ooze uses Sticky Goo.  I can't progress without worrying about being unlucky, but I imagine that this will continue and make some bosses unable to be defeated, as they'll just freeze the game before I can do it.
I swapped over to VisualBoy Advance to bypass this, as I don't seem to encounter the problem then, but it runs very poorly, I'm not sure if it's my settings or what.  I have audio lag, where sound effects are delayed, but I also have audio speedup at random intervals.  Everything also sounds very choppy, and visually mGBA looks a whole lot better, so I'd prefer to use it. 
I use a US/Europe ROM, and I'm on a Macbook Pro 2012. 
The Reloaded hack is great!  I just can't play very long due to the possible bug.  Any ideas?  I hope people are still active on this thread.