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I was on the 1.32 patch. I just replayed it to make sure. Once you have Wish, enemies need a significant boost in their AOE psynergy or high single-target damage to be a threat. Things like mad blast, fireball, nova, etc. have decent damage, but one of them needs to be used twice per turn for 2-3 consecutive turns to realistically do anything. Idk, just my thoughts on it.

Thanks for the info on the other two points. I usually just stuck with monelemental classes until having all the djinn, so I hadn't previously encountered losing psynergy like that.

I was bored today, so I decided to play through TBS and write some brief notes while playing. Every battle (except my last fight against Deadbeard) had all djinn set at the beginning. I did Kolima up to the Tret battle, completed Mercury lighthouse, then defeated Tret. I did vault/vale/lunpa immediately after getting the cloak ball. Otherwise, I stuck to the standard playthrough order.

Saturos: Level 9-10. Ivan fainted ~2/3 through battle. Had Earth djinn set on Ivan to give him more HP, but he was still dropped to 2 HP by eruption. Appropriately challenging at the time, though I think I got a little lucky with his target selections.

Tret: Level 10-11. Extremely easy. I'm guessing his strength was set to be battled before Mercury when you only have 3 members at lower levels. This was just use 2 djinn on each member -> summon -> use 2 djinn again -> don't even need 4 summons.

Killer Ape: Level 12-13. fairly easy. Doesn't do enough damage to warrant much healing, especially with granite every third turn.

Corona: This djinn hit really hard and felt much harder than any of the other djinn. I only had Garet alive at the end, but fought it pretty sloppily. I think the difference between here and Saturos is how often AOE psynergy is used.

Hydros Statue: Level 15-16. seemed appropriate. This fight without wish would have been really hard, but Ivan spamming it as the first move every turn and possible additional heals from Isaac pretty much meant no one could die. If given a stronger psynergy, it might require level grinding since you don't have revive.

Manticore: Level 16-17. pretty weak. Maybe replace mad blast with something stronger.

Kraken: Level 16-17. Slightly weaker than I'd hoped for. Spamming wish on Ivan or Mia is still a dominant strategy. He doesn't seem to have break, which means his damage is never high enough to be a threat after using corona/breeze.

Colosso: Level 19. Not much to say, just Ground -> Flint -> Ramses -> Cure Well as usual. There's little room for strategic diversity, so I don't think this could be changed in a meaningful way.

Toadonpa: Level 19-20. Probably at the correct difficulty. The base damage on his psynergy is low, but poisons often enough to make up for it. Increasing the single-target damage on poison-tail significantly may be a nice touch.

Storm Lizard: Level 21-22. Reasonable difficulty. I made it harder than it should have been when it took 4 attempts to revive one person because only Isaac had revive (Ivan/Mia had a higher speed, so I couldn't fully heal after using revive).

Deadbeard: Level 25-26. @#$% this guy. Took 5 tries and was very enjoyable :). I think a major error in my first couple tries was using Luff, which led to 2 Sweeps in a turn knocking out adjacent members. I also did a couple first-turn summons the fifth time to vent some frustration ;). My boring class setup had very few debuffs available and no early summons had resulted in his ward/guard/impact/etc. building up too much over the fight length. Out of curiosity, were his resistances significantly changed? Judgement wrecked every time it was used, but other Boreas and Meteor only did 25-45% as much damage. I just don't recall that big of a difference, but maybe it was always that way.

S&M and Fusion Dragon: Level 27-28. Slightly underwhelming, but close to the right difficulty. It probably would have been appropriate if I'd skipped crossbone isle and been 2 levels lower. I had to revive a few guys against the dragon and found reviving much easier than against deadbeard or storm lizard (i.e., it worked the first turn).

Why does Mia going from 4-5 fire djinn (Shugenja) to 6-7 (Righteous) cause her to lose the Wish series?

If you want me to expand on any of these, let me know. I'll probably play through TLA (sans Dullahan) over the next week or two and can give similar feedback.